About this Journal Contact this Journal Current issue Archive Search
Omics Publications   »  Life Sciences    »    Volume 1  

© The Author 2008. Published by OMICS Publishing Group. All rights reserved. For Permissions,


The Genetic Equidistance Result of Molecular Evolution is Independent of Mutation Rates

Shi Huang


The well-established genetic equidistance result shows that sister species are approximately equidistant to a simpler outgroup as measured by DNA or protein dissimilarity. The equidistance result is the most direct evidence, and remains the only evidence, for the constant mutation rate interpretation of this result, known as the molecular clock. However, data independent of the equidistance result have steadily accumulated in recent years that often violate a constant mutation rate. Many have automatically inferred non-equidistance whenever a non-constant mutation rate was observed, based on the unproven assumption that the equidistance result is an outcome of constant mutation rate. Here it is shown that the equidistance result remains valid even when different species can be independently shown to have different mutation rates. A random sampling of 50 proteins shows that nearly all proteins display the equidistance result despite the fact that many proteins have nonconstant mutation rates. Therefore, the genetic equidistance result does not necessarily mean a constant mutation rate. Observations of different mutation rates do not invalidate the genetic equidistance result. New ideas are needed to explain the genetic equidistance result that must grant different mutation rates to different species and must be independently testable.

  This Artical
» Full Text (PDF)
» Similar articles in scholar google
» Similar articles in Pub Med
Google Scholar
» Articles by Shi Huang
Pub Med
» Articles by Shi Huang