"Journal of Psychiatry is one of the best journals in Dementia. The aim of Journal of psychiatry is to connect the knowledge gaps across a wide range of bench-to-bedside investigation. The journal publishes the results of studies in: behavior, physiology, protein chemistry, neurology, neuropathology, psychiatry, geriatrics, neuropsychology, epidemiology, sociology, health services research, health economics.Dementia, being not a specific disease but a syndrome characterized by deficits in several cognitive domains, is a major public health and socio-economic problem of our century. It is caused by dysfunction/loss of synapses and neurons inducing default neuronal networks. Despite updated consensus criteria for the clinical diagnosis of the major neurodegenerative disorders and new biomarkers, the diagnostic accuracy ranges from 65 to 96% (for Alzheimerâs disease /AD), with a sensitivity versus other dementias of around 85.4% and a specificity of up to 77.7%. Pathologic assessment, using genetic and molecular biological methods, based on homogenous definitions, harmonized interlaboratory and assessment standards, can achieve a classification in up to 95%, without, however, clarifying the etiology of most of these disorders. The new National Institute on Aging-Alzheimer Association guidelines (âABCâ score) for the neuropathologic diagnosis of AD combine Î²-amyloid plaque phases and Braak neurofibrillary scores, also considering other concomitant pathologies, but do not consider distinct clinico-pathologic subtypes of AD. Revised research criteria are available for dementia with Lewy bodies, Parkinson disease-dementia, frontotemporal lobe degeneration, vascular cognitive impairment, prion diseases, and other degenerative dementias. However, due to overlap between proteinopathies, frequent confounding lesions and co-occurence of multiple pathologies in aged brains, human postmortem studies entail biases that affect both their general applicability and validity. Although most degenerative dementias are incurable at present, prospective studies using validated protocols and data fusion may overcome the limitations of the current diagnostic framework as a basis for future personalized therapy options. âKurt A Jellinger ,Neuropathology of Dementia Disordersâ.
OMICS publishes original scientific and specialized articles on all aspects of psychiatry, and related scientific disciplines. Also provides the researchers and young minds descriptions of new experimental methods of neurological importance, or new interpretations of existing result.
Last date updated on June, 2014