alexa Characterization of Nanoparticles by Mass Spectrometry | Open Access Journals
ISSN: 2150-3494
Chemical Sciences Journal
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Characterization of Nanoparticles by Mass Spectrometry

Qin Hu*

Department of Chemistry, State University of New York at Buffalo, Natural Science Complex, Buffalo, NY 14260, USA

*Corresponding Author:
Qin Hu
Department of Chemistry
State University of New York at Buffalo
Natural Science Complex
Buffalo, NY 14260, USA
Tel: 716-416-3032

Received Date: March 15, 2017 Accepted Date: March 16, 2017 Published Date: March 30, 2017

Citation: Qin Hu (2017) Characterization of Nanoparticles by Mass Spectrometry. Chem Sci J 8: e115. doi: 10.4172/2150-3494.1000e115

Copyright: © 2017 Qin H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Chemical Sciences Journal


While mass spectrometry has been widely used for decades in biomolecules analyses, the story of mass spectrometric characterization of nanoparticles (NPs) is still short. The mass spectrometry has recently received much attention in the nanoparticle world due to its powerful usefulness especially in elucidating the chemical structures of the smaller-sized NPs (<5 nm) [1-3]. We are witnessing the major improvements of mass spectrometry that are taking places both in the structural analyses of NPs but also in the mass elucidation of NPs. The advances are mainly coming in the form of improvements in instruments such as advances in ion sources.

Among the most basic criterions of a mass spectrometric technique, the two important factors are the resolution and the sensitivity, of which the former one is increasingly important in identifying the accurate chemical structures of NPs, and the later one is of super significance in elucidating the exact mass of NPs. This need for developing mass spectrometric techniques with better resolution and higher sensitivity and searching for pathways to improve was noted in some important research of the leaders in this field.

An important success in this area is the work by Anderson L. Marsh [1], a leading expert in the mass spectrometric characterization of NPs. He gives an insight into how the matrix assisted laser desorption/ ionization time-of-flight (MALDI-TOF) mass spectrometry functions in the characterization of colloidal platinum NPs. One thing that is becoming clear is that the identification of the chemical structures of NPs by MALDI-TOF mass spectrometry can be achieved easily. However, it has to point out that MALDI-TOF mass spectrometry exhibits lower sensitivity with increasing mass, and fails to capture the larger mass ions; therefore, the elucidation of the exact mass of NPs is challenging. This phenomenon also happens to the characterization of non-heavy metal NPs. A typical example is the MALDI-TOF characterization of the chemical structures of carbon nanoparticles by our group [2]. In our further attempts, we found that the sensitivity of the electrospray ionization quadrupole time-of-flight tandem (ESI-QTOF) mass spectrometry [3,4] towards carbon nanoparticles is much better than MALDI-TOF with more mass ions in high mass range can be captured, but it is still limited to reveal its exact mass information.

To this end, the development of mass spectrometry techniques with improved resolution and sensitivity is highly necessary to advance the accurate characterization of nanoparticles. In addition, the slow and patient examination on the certain mechanical factors that limits the resolution and sensitivity of an existing mass spectrometry technique is of equal importance. Making improvements in the resolution and the sensitivity of an order of magnitude may not be as astonishing as developing a new method, but they are of significant importance.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 345
  • [From(publication date):
    March-2017 - Jun 25, 2017]
  • Breakdown by view type
  • HTML page views : 290
  • PDF downloads :55

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version